Obstacles to Progress in MS: A Personal Story

Hepatology: a personal story

When I first began my career in hepatology in October 1959, investigative and treatment measures for patients with liver disease were limited. It was not until the discovery of hepatitis B virus in 1967 and hepatitis C virus in 1989 that the specialty began to expand, particularly with the development of effective antiviral therapy. Phenomenal advances in the knowledge of immune reactions also ...

In vivo tau imaging: Obstacles and progress

The military conflicts of the last decade have highlighted the growing problem of traumatic brain injury in combatants returning from the battlefield. The considerable evidence pointing at the accumulation of tau aggregates and its recognition as a risk factor in neurodegenerative conditions such as Alzheimer's disease have led to a major effort to develop selective tau ligands that would allow...

From pills to penicillin. The Beecham story. A personal account

Flipping primary health care: A personal story.

There is considerable interest in ideas borrowed from education about "flipping the classroom" and how they might be applied to "flipping" aspects of health care to reach the Triple Aim of improved health outcomes, improved experience of care, and reduced costs. There are few real-life case studies of "flipping health care" in practice at the individual patient level. This article describes the...

Problems of scientific revolution. Progress and obstacles to progress in the sciences

R. HARRI, (editor), Problems of scientific revolution. Progress and obstacles to progress in the sciences, Oxford, Clarendon Press, 1975, 8vo, pp. vii, 104, £1.75. The six essays in this book represent the Herbert Spencer Lectures for 1973, and their main theme is one that was central to Spencer's thought, and in keeping with his political and moral convictions. It is the growth of scientific k...